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邮箱:sibcb@sibcb.ac.cn

全所PI名录 >

 
许琛琦
研究员,研究组长,博士生导师,所长助理
E-mail: cqxu@@sibcb.ac.cn
Lab homepage: Y, Meckel T, Chen Y, Hu Z, Li Z*, Xu C*, Gong H*, Liu W*. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232. The Journal of Experimental Medicine, 213(12), pp 2707-2727, 2016.
  • Wu W, Shi X, Xu C*. Regulation of T cell signalling by membrane lipids. Nature Reviews Immunology, 16(11), pp 690-701, 2016.
  • Liu W*, Wang H, Xu C*. Antigen Receptor Nanoclusters:Small Units with Big Functions. Trends in Immunology, 37(10), pp 680-689, 2016.
  • Yang W#, Bai Y#, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang C, Chang T, Zhang T, Zhou P Song B, Liu W, Sun S, Liu X, Li B*, Xu C*. Potentiating the anti tumour response of CD8+ T cells by modulating cholesterol metabolism. Nature, 531(7596), pp 651-655, 2016.
  • Cui Y#, Chen X#, Zhang J, Sun X, Liu H, Bai L, Xu C, Liu X*. Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis. Cell Reports, 15(2), pp 256-263, 2016.
  • Chen X#, Pan W#, Sui Y, Li H, Shi X, Guo X, Qi H, Xu C*, Liu W*. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications, 6(8552), 2015.
  • Liu C#, Zhao X#, Xu L, Yi J, Shaheen S, Han W, Wang F, Zheng W, Xu C, Liu W. A negative-feedback function of PKCβ in the formation and accumulation of signaling-active B cell receptor microclusters within B cell immunological synapse. Journal of Leukocyte Biology, 97(5), pp 887-900, 2015.
  • Wu W#, Yan C#, Shi X, Li L, Liu W, Xu C*. Lipid in T-cell receptor transmembrane signaling. Progress in Biophysics and Molecular Biology, 118(3), pp 130-138, 2015.
  • Wang Y#, Gao J#, Guo X#, Tong T, Shi X, Li L, Qi M, Wang Y, Cai M, Jiang J, Xu C*, Ji H*, Wang H*. Regulation of EGFR nanocluster formation by ionic protein-lipid interaction. Cell Research, 24(8), pp 959-976, 2014.
  • Li L#, Shi X#, Guo X, Li H, Xu C*. Ionic protein-lipid interaction at the plasma membrane: what can the charge do? Trends in Biochemical Sciences, 39(3), pp 130-140, 2014.
  • Wertek F, Xu C*. Digital response in T cells: to be or not to be. Cell Research, 24(3), pp 265-266, 2014.
  • Li P, Fu Z, Zhang Y, Zhang J, Xu C, Ma Y, Li B, Song B. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nature Medicine, 20(1), pp 80-86, 2014.
  • Shi X#, Bi Y#, Yang W#, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J*, Xu C*. Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids. Nature, 493(7430), pp 111-115, 2013.
  • Liu B#, Liu Y#, Du Y, Mardaryev A, Yang W, Chen H, Xu Z, Xu C, Zhang X, Botchkarev V, Zhang Y*, Xu G*. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development, 140(4), pp 780-788, 2013.
  • Zhang K#, Pan Y#, Qi J, Yue J, Zhang M, Xu C, Li G*, Chen J*. Disruption of disulfide-restriction at integrin knees induces activation and ligand-independent signaling of α4β7. Journal of Cell Science, 126(Pt21), pp 5030-5041, 2013.
  • Wang X#, Jimenez-Vargas J#, Xu C, Possani L*, Zhu S*. Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K(+) channel toxins. Biochemical and Biophysical Research Communications, 429(1-2), pp 111-116, 2012.
  • Gagnon E, Xu C, Yang W, Chu H, Call M, Chou J, Wucherpfennig K*. Response multilayered control of T cell receptor phosphorylation. Cell, 142(5), pp 669-671, 2010.
  • Xu C#, Gagnon E#, Call M, Schnell J, Schwieters C, Carman C, Chou J*, Wucherpfennig K*. Regulation of T cell Receptor Activation by Dynamic Membrane Binding of the CD3e Cytoplasmic Tyrosine-Based Motif. Cell, 135(4), pp 702-713, 2008.
  • Wang S, Huang L, Wicher D, Chi C*, Xu C*. Structure-function relationship of bifunctional scorpion toxin BmBKTx1. Acta Biochimica et Biophysica Sinica (Shanghai), 40(11), pp 955-963, 2008.
  • O’Connor K#, McLaughlin KA#, De Jager P, Chitnis T, Bettelli E, Xu C, Robinson W, Cherry S, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong S, Tavakoli N, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale R, Freedman M, Steinman L, Buckle G, Kuchroo V, Hafler D*, Wucherpfennig K*. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine, 13(2), pp 211-217, 2007.
  • Xu C, Call M, Wucherpfennig K. A membrane-proximal tetracysteine motif contributes to assembly of cd3de and cd3ge dimers with the T cell receptor. Journal of Biological Chemistry, 281(48), pp 36977-36984, 2006.
  • Call M#, Schnell J#, Xu C, Lutz R, Chou J*, Wucherpfennig K*. The Structure of the ζζ Transmembrane Dimer Reveals Polar Features Essential for Dimerization and Assembly with the T cell Receptor. Cell, 127(2), pp 355-368, 2006.
  • Jiang H, Xu C, Wang C, Fan C, Zhao T, Chen J, Chi C. Two novel O-superfamily conotoxins from Conus vexillum. Toxicon, 47(4), pp 425-436, 2006.
  • Jiang H#, Wang C#, Xu C, Fan C, Dai X, Chen J, Chi C. A novel M-superfamily conotoxin with a unique motif from Conus vexillum. Peptides, 27(4), pp 682-689, 2006.
  • Xu C#, Brône B#, Wicher D, Bozkurt O, Lu W, Huys I, Han Y, Tytgat J, Van Kerkhove E, Chi C. BmBKTx1, a novel Ca2+activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch. Journal of Biological Chemistry, 279(33), pp 34562-34569, 2004.
  • Xu C, He L, Brône B, Martin-Eauclaire M, Van Kerkhove E, Zhou Z, Chi C. A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel. Toxicon, 43(8), pp 961-971, 2004.
  • Cai Z#, Xu C#, Xu Y, Lu W, Chi C, Shi Y, Wu J. Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch. Biochemistry, 43(13), pp 3764-3771, 2004.
  • Huys I#, Xu C#, Wang C, Vacher H, Martin-Eauclaire M, Chi C, Tytgat J. BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents. Biochemical Journal, 378(3), pp 45-52, 2004.
  • Frénal K#, Xu C#, Wolff N, Wecker K, Gurrola G, Zhu S, Chi C, Possani L, Tytgat J*, Delepierre M*. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels. PROTEINS: Structure, Function, and Bioinformatics, 56(2), pp 367-375, 2004.
  • Szyk A, Lu W, Xu C, Lubkowski J. Structure of the Scorpion Toxin BmBKTx1 Solved from Single Wavelength Anomalous Scattering of Sulfur. Journal of Structural Biology, 145(3), pp 289-294, 2004.
  • Xu C, Zhu S, Chi C, Tytgat J. Turret and pore block of K+ channels: what is the difference? Trends in Pharmacological Sciences, 24(9), pp 446-448, 2003.

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